Targeted Attenuation of Electrical Activity in Drosophila Using a Genetically Modified K+ Channel
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چکیده
منابع مشابه
Targeted Attenuation of Electrical Activity in Drosophila Using a Genetically Modified K+ Channel
We describe here a general technique for the graded inhibition of cellular excitability in vivo. Inhibition is accomplished by expressing a genetically modified Shaker K(+) channel (termed the EKO channel) in targeted cells. Unlike native K(+) channels, the EKO channel strongly shunts depolarizing current: activating at potentials near E(K) and not inactivating. Selective targeting of the chann...
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ژورنال
عنوان ژورنال: Neuron
سال: 2001
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(01)00415-9